Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies

Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies

Abstract Background The genome of SARS-CoV-2 is susceptible to mutations during viral replication due to the errors generated by RNA-dependent RNA polymerases. These mutations enable the SARS-CoV-2 to evolve into new strains. Viral quasispecies emerge from de novo mutations that occur in individual...

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Bibliographic Details
Main Authors: Billy T. Lau, Dmitri Pavlichin, Anna C. Hooker, Alison Almeda, Giwon Shin, Jiamin Chen, Malaya K. Sahoo, Chun Hong Huang, Benjamin A. Pinsky, Ho Joon Lee, Hanlee P. Ji
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Medicine
Subjects:
COVID-19
SARS-CoV-2
Pandemic
Viral mutations
Quasispecies
Genetic fingerprints
Online Access:https://doi.org/10.1186/s13073-021-00882-2

Internet

https://doi.org/10.1186/s13073-021-00882-2

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