Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis

Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis

Esophageal squamous cell carcinoma (ESCC) is a recalcitrant cancer. The Chinese herbal monomer fangchinoline (FCL) has been reported to have anti-tumor activity in several human cancer cell types. However, the therapeutic efficacy and underlying mechanism on ESCC remain to be elucidated. In the pres...

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Bibliographic Details
Main Authors: Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M. Hoffman, Yanmei Zhang, Lijun Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
fangchinoline (FCL)
esophageal squamous cell carcinoma (ESCC)
cell cycle
intrinsic apoptosis
extrinsic apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.666549/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.666549/full

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