Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

Abstract Background Primaquine (PQ) is recommended as an addition to standard malaria treatments in pre-elimination settings due to its pronounced activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for onward transmission to mosquitoes. However, PQ may trigger...

Full description

Bibliographic Details
Main Authors: Shehu S. Awandu, Jaishree Raman, Takalani I. Makhanthisa, Philip Kruger, John Frean, Teun Bousema, Jandeli Niemand, Lyn-Marie Birkholtz
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Malaria Journal
Subjects:
Malaria
Primaquine
Malaria elimination
G6PD deficiency
CYP2D6
Online Access:http://link.springer.com/article/10.1186/s12936-018-2271-z

Internet

http://link.springer.com/article/10.1186/s12936-018-2271-z

Similar Items