Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations

Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations

Abstract Background Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, suggesting germline transmission. We have previously shown that prenata...

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Bibliographic Details
Main Authors: Jessy Cartier, Thomas Smith, John P. Thomson, Catherine M. Rose, Batbayar Khulan, Andreas Heger, Richard R. Meehan, Amanda J. Drake
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Genome Biology
Subjects:
Early life programming
DNA methylation
Histone modifications
Small RNA
Epigenetic
Germline transmission
Online Access:http://link.springer.com/article/10.1186/s13059-018-1422-4

Internet

http://link.springer.com/article/10.1186/s13059-018-1422-4

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