A structural biology approach to understand human lymphatic filarial infection.

The presence of aspartic protease inhibitor in filarial parasite Brugia malayi (Bm-Aspin) makes it interesting to study because of the fact that the filarial parasite never encounters the host digestive system. Here, the aspartic protease inhibition kinetics of Bm-Aspin and its NMR structural charac...

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Bibliographic Details
Main Authors: Raghavendra Sashi Krishna Nagampalli, Krishnasamy Gunasekaran, Rangarajan Badri Narayanan, Angela Peters, Rajagopalan Bhaskaran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3916234?pdf=render