Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma

Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma

Clear cell renal cell carcinoma (ccRCC) is among the most aggressive histologic subtypes of kidney cancer, representing about 3% of all human cancers. Patients at stage IV have nearly 60% of mortality in 2–3 years after diagnosis. To date, most ccRCC studies have used DNA microarrays and targeted se...

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Bibliographic Details
Main Authors: Alejandro Mendoza-Alvarez, Beatriz Guillen-Guio, Adrian Baez-Ortega, Carolina Hernandez-Perez, Sita Lakhwani-Lakhwani, Maria-del-Carmen Maeso, Jose M. Lorenzo-Salazar, Manuel Morales, Carlos Flores
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
ccRCC
whole-exome sequencing
kidney cancer
somatic mutation
mortality
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00439/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00439/full

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