Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia

Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia

Novel treatment strategies are of paramount importance to improve clinical outcomes in pediatric AML. Since chemotherapy is likely to remain the cornerstone of curative treatment of AML, insights in the molecular mechanisms that determine its cytotoxic effects could aid further treatment optimizatio...

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Bibliographic Details
Main Authors: David G.J. Cucchi, Costa Bachas, Marry M. van den Heuvel-Eibrink, Susan T.C.J.M. Arentsen-Peters, Zinia J. Kwidama, Gerrit J. Schuurhuis, Yehuda G. Assaraf, Valérie de Haas, Gertjan J.L. Kaspers, Jacqueline Cloos
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
pediatric acute myeloid leukemia
drug resistance
drug response
gene expression
chemotherapy
cytarabine
Online Access:https://www.mdpi.com/2072-6694/12/5/1247

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https://www.mdpi.com/2072-6694/12/5/1247

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