Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

Abstract Background Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required for the derivation of induced pluripotent stem cells (iPSCs). However,...

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Bibliographic Details
Main Authors: Areechun Sotthibundhu, Katya McDonagh, Alexander von Kriegsheim, Amaya Garcia-Munoz, Agnieszka Klawiter, Kerry Thompson, Kapil Dev Chauhan, Janusz Krawczyk, Veronica McInerney, Peter Dockery, Michael J. Devine, Tilo Kunath, Frank Barry, Timothy O’Brien, Sanbing Shen
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Stem Cell Research & Therapy
Subjects:
Actin cytoskeleton
Adherens junctions
Autophagy
Differentiation
Embryoid body
Induced pluripotent stem cells
Online Access:http://link.springer.com/article/10.1186/s13287-016-0425-x

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http://link.springer.com/article/10.1186/s13287-016-0425-x

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