Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salvia miltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells

Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salvia miltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells

Although Salvia miltiorrhiza has been reported to have anti-cancer mechanisms, such as caspase activation, cell cycle arrest, an anti-angiogenesis effect, and Bcl-2 family regulation, its underlying mechanism of endoplasmic reticulum (ER) stress-mediated apoptosis has never been demonstrated. Thus,...

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Bibliographic Details
Main Authors: Changmin Kim, Hyo-Sook Song, Hojung Park, Bonglee Kim
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
Salvia miltiorrhiza
oxidative stress
endoplasmic reticulum stress
C/EBP homologous protein
reactive oxygen species
miR-216b
c-Jun
Online Access:http://www.mdpi.com/1422-0067/19/4/1240

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http://www.mdpi.com/1422-0067/19/4/1240

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