CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan

CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan

Summary: The ATP-dependent chromatin remodeling factor CHD1 is essential for the assembly of variant histone H3.3 into paternal chromatin during sperm chromatin remodeling in fertilized eggs. It remains unclear, however, if CHD1 has a similar role in normal diploid cells. Using a specifically tailor...

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Bibliographic Details
Main Authors: Ines Schoberleitner, Ingo Bauer, Anming Huang, Evgeniya N. Andreyeva, Johanna Sebald, Katharina Pascher, Dietmar Rieder, Melanie Brunner, Valerie Podhraski, Gregor Oemer, Daniel Cázarez-García, Leila Rieder, Markus A. Keller, Robert Winkler, Dmitry V. Fyodorov, Alexandra Lusser
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
epigenetics
histone chaperone
heterochromatin
aging
longevity
metabolic disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012237

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http://www.sciencedirect.com/science/article/pii/S2211124721012237

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