Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs
Infection with Ross River virus (RRV) causes debilitating polyarthritis and arthralgia in individuals. Alphaviruses are highly sensitive to type I interferon (IFN). Mutations at the conserved P3 position of the cleavage site between nonstructural protein 1 (nsP1) and nsP2 (1/2 site) modulate type I...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2018-08-01
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Series: | mBio |
Subjects: | |
Online Access: | https://doi.org/10.1128/mBio.00044-18 |