Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

Infection with Ross River virus (RRV) causes debilitating polyarthritis and arthralgia in individuals. Alphaviruses are highly sensitive to type I interferon (IFN). Mutations at the conserved P3 position of the cleavage site between nonstructural protein 1 (nsP1) and nsP2 (1/2 site) modulate type I...

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Bibliographic Details
Main Authors: Xiang Liu, Margit Mutso, Age Utt, Anni Lepland, Lara J. Herrero, Adam Taylor, Jayaram Bettadapura, Penny A. Rudd, Andres Merits, Suresh Mahalingam
Format: Article
Language:English
Published: American Society for Microbiology 2018-08-01
Series:mBio
Subjects:
Ross river virus
Sindbis virus
alphavirus
interferons
Online Access:https://doi.org/10.1128/mBio.00044-18

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