Homopolish: a method for the removal of systematic errors in nanopore sequencing by homologous polishing

Abstract Nanopore sequencing has been widely used for the reconstruction of microbial genomes. Owing to higher error rates, errors on the genome are corrected via neural networks trained by Nanopore reads. However, the systematic errors usually remain uncorrected. This paper designs a model that is...

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Bibliographic Details
Main Authors: Yao-Ting Huang, Po-Yu Liu, Pei-Wen Shih
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-021-02282-6