Histone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells

Histone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells

Background/Aims: Diabetic patients suffer from severe neointimal hyperplasia following angioplasty. The epigenetic abnormalities are increasingly considered to be relevant to the pathogenesis of diabetic cardiovascular complications. But the epigenetic mechanisms linking diabetes and coronary resten...

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Bibliographic Details
Main Authors: Hu Qi, Zhang Jing, Wu Xiaolin, Xu Changwu, Hu Xiaorong, Yang Jian, Chen Jing, Jiang Hong
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Vascular smooth muscle cell
JMJD2A
Restenosis
Neointimal hyperplasia
Diabetes
Inflammation
Online Access:http://www.karger.com/Article/FullText/430390

Internet

http://www.karger.com/Article/FullText/430390

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