LRP1 modulates APP trafficking along early compartments of the secretory pathway

LRP1 modulates APP trafficking along early compartments of the secretory pathway

The amyloid beta peptide (Aβ) is a central player in Alzheimer's disease (AD) pathology. Aβ liberation depends on APP cleavage by β- and γ-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at multiple steps. Newly synthesized LRP1 can...

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Bibliographic Details
Main Authors: Elaine Waldron, Catherine Heilig, Andrea Schweitzer, Nirupa Nadella, Sebastian Jaeger, Anne M. Martin, Sascha Weggen, Klaudia Brix, Claus U. Pietrzik
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Neurobiology of Disease
Subjects:
Low density lipoprotein receptor related protein
Amyloid precursor protein
Trafficing
Secretory pathway
Retention
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000739

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108000739

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