Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors

Stem cell expansion on 3D porous scaffolds cultured in bioreactor systems has been shown to be beneficial for maintenance of the original cell functionality in tissue engineering strategies (TE). However, the production of extracellular matrix (ECM) makes harvesting the progenitor cell population fr...

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Bibliographic Details
Main Authors: Mohammad Mehrian, Toon Lambrechts, Ioannis Papantoniou, Liesbet Geris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
computational modeling
mesenchymal stromal cell
perfusion bioreactor
growth factors
optimization
tissue engineering
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00376/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00376/full

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