Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

Abstract Background Ischemic stroke poses a severe risk to human health worldwide, and currently, clinical therapies for the disease are limited. Delta opioid receptor (DOR)-mediated neuroprotective effects against ischemia have attracted increasing attention in recent years. Our previous studies re...

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Bibliographic Details
Main Authors: Zelin Lai, Lingling Gu, Lu Yu, Huifen Chen, Zhenhua Yu, Cheng Zhang, Xiaoqing Xu, Mutian Zhang, Min Zhang, Mingliang Ma, Zheng Zhao, Jun Zhang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cell & Bioscience
Subjects:
Ischemia/reperfusion injury
Hippocampus
Delta opioid receptor
Neuronal autophagy
AMPK/mTOR/ULK1 signaling pathway
Online Access:http://link.springer.com/article/10.1186/s13578-020-00441-z

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http://link.springer.com/article/10.1186/s13578-020-00441-z

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