A one-degree-of-freedom test for supra-multiplicativity of SNP effects.

A one-degree-of-freedom test for supra-multiplicativity of SNP effects.

Deviation from multiplicativity of genetic risk factors is biologically plausible and might explain why Genome-wide association studies (GWAS) so far could unravel only a portion of disease heritability. Still, evidence for SNP-SNP epistasis has rarely been reported, suggesting that 2-SNP models are...

Full description

Bibliographic Details
Main Authors: Christine Herold, Alfredo Ramirez, Dmitriy Drichel, André Lacour, Tatsiana Vaitsiakhovich, Markus M Nöthen, Frank Jessen, Wolfgang Maier, Tim Becker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205078/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205078/pdf/?tool=EBI

Similar Items