Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-inflammatory effects, drugs that neutralize TNF were developed and are clinically used to treat inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. Howeve...

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Bibliographic Details
Main Authors: Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TNF
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00401/full