Olive secoiridoid oleuropein and its semisynthetic acetyl-derivatives reduce LPS-induced inflammatory response in murine peritoneal macrophages via JAK-STAT and MAPKs signaling pathways

Olive secoiridoid oleuropein and its semisynthetic acetyl-derivatives reduce LPS-induced inflammatory response in murine peritoneal macrophages via JAK-STAT and MAPKs signaling pathways

The present study was designed to investigate the potential anti-inflammatory, antioxidant and immunomodulatory activities of three new derivatives from OL in lipopolysaccharide (LPS)-induced mouse peritoneal macrophages in comparison with natural OL. Nitrites levels were analyzed by Griess method a...

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Bibliographic Details
Main Authors: Maria Luisa Castejon, Marina Sánchez-Hidalgo, Marina Aparicio-Soto, Alejandro González-Benjumea, Jose G. Fernández-Bolaños, Catalina Alarcón-de-la-Lastra
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Journal of Functional Foods
Subjects:
HO-1
LPS
Macrophage
Nrf2
Oleuropein
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619302191

Internet

http://www.sciencedirect.com/science/article/pii/S1756464619302191

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