CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes.

CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes.

Obesity is associated with various human disorders, such as type 2 diabetes, cardiovascular diseases, hypertension, and cancers. In this study, we observed that knockout (KO) of CCN5, which encodes a matricellular protein, caused mild obesity in mice. The CCN5 KO mice also exhibited mild diabetes ch...

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Bibliographic Details
Main Authors: Jihwa Kim, Sanghyun Joo, Gwang Hyeon Eom, Seung Hoon Lee, Min-Ah Lee, Miyoung Lee, Ki Woo Kim, Do Han Kim, Hyun Kook, Tae Hwan Kwak, Woo Jin Park
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207228

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https://doi.org/10.1371/journal.pone.0207228

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