An evolutionary path to altered cofactor specificity in a metalloenzyme

Many metalloenzymes are highly specific for their cognate metal ion but the molecular principles underlying this specificity often remain unclear. Here, the authors characterize the structural and biochemical basis for the different metal specificity of two evolutionarily related superoxide dismutas...

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Bibliographic Details
Main Authors: Anna Barwinska-Sendra, Yuritzi M. Garcia, Kacper M. Sendra, Arnaud Baslé, Eilidh S. Mackenzie, Emma Tarrant, Patrick Card, Leandro C. Tabares, Cédric Bicep, Sun Un, Thomas E. Kehl-Fie, Kevin J. Waldron
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16478-0