Satellite Subgenomic Particles Are Key Regulators of Adeno-Associated Virus Life Cycle

Satellite Subgenomic Particles Are Key Regulators of Adeno-Associated Virus Life Cycle

Historically, adeno-associated virus (AAV)-defective interfering particles (DI) were known as abnormal virions arising from natural replication and encapsidation errors. Through single virion genome analysis, we revealed that a major category of DI particles contains a double-stranded DNA genome in...

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Bibliographic Details
Main Authors: Junping Zhang, Xiangping Yu, Ping Guo, Jenni Firrman, Derek Pouchnik, Yong Diao, Richard Jude Samulski, Weidong Xiao
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
adeno-associated virus
subgenomic particles
“snapback” configuration
life cycle
Online Access:https://www.mdpi.com/1999-4915/13/6/1185

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https://www.mdpi.com/1999-4915/13/6/1185

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