Estimating growth patterns and driver effects in tumor evolution from individual samples

There are many methods to detect cancer-driving mutations. Here, the authors harness the variant allele frequency of mutations in tumor cells of a single individual to present a method that can estimate growth patterns and identify driver gene evolution at a patient specific level.

Bibliographic Details
Main Authors: Leonidas Salichos, William Meyerson, Jonathan Warrell, Mark Gerstein
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14407-9