Emergence of Endocytosis-Dependent mGlu1 LTD at Nucleus Accumbens Synapses After Withdrawal From Cocaine Self-Administration

Emergence of Endocytosis-Dependent mGlu1 LTD at Nucleus Accumbens Synapses After Withdrawal From Cocaine Self-Administration

Extended-access cocaine self-administration induces a progressive intensification of cue-induced drug craving during withdrawal termed “incubation of cocaine craving”. Rats evaluated after >1 month of withdrawal (when incubation of craving is robust) display alterations in excitatory synapses...

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Bibliographic Details
Main Authors: Andrew F. Scheyer, Daniel T. Christian, Marina E. Wolf, Kuei Y. Tseng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
calcium-permeable AMPA receptor
synaptic transmission
cocaine withdrawal
long-term depression
nucleus accumbens
metabotropic glutamate receptor 1
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2018.00036/full

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