N-Terminal Tagging with GFP Enhances Selectivity of Agitoxin 2 to Kv1.3-Channel Binding Site

N-Terminal Tagging with GFP Enhances Selectivity of Agitoxin 2 to Kv1.3-Channel Binding Site

Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci Rep. 2016, 6, 33314). Here we report on N-terminal...

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Bibliographic Details
Main Authors: Oksana V. Nekrasova, Alexandra L. Primak, Anastasia A. Ignatova, Valery N. Novoseletsky, Olga V. Geras’kina, Ksenia S. Kudryashova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexander S. Arseniev, Alexey V. Feofanov
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Toxins
Subjects:
agitoxin
GFP
potassium channel
selective ligand
Online Access:https://www.mdpi.com/2072-6651/12/12/802

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https://www.mdpi.com/2072-6651/12/12/802

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