Correlation of the electrophysiological profiles and sodium channel transcripts of individual rat dorsal root ganglia neurons

Voltage gated sodium channels (Na+ channels) play an important role in nociceptive transmission. They are intimately tied to the genesis and transmission of neuronal firing. Five different isoforms (Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) have been linked to nociceptive responses. A change in th...

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Bibliographic Details
Main Authors: Olivier eTheriault, Mohamed eChahine
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00285/full