5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

<p>Abstract</p> <p>Background</p> <p>Emergence of drug-resistant strains of influenza viruses, including avian H5N1 with pandemic potential, 1918 and 2009 A/H1N1 pandemic viruses to currently used antiviral agents, neuraminidase inhibitors and M2 Ion channel blockers, u...

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Bibliographic Details
Main Authors: García-Sastre Adolfo, Gubareva Larisa, Gangappa Shivaprakash, Wiens Mayim E, Jeisy-Scott Victoria, Hoelscher Mary A, Bowzard John B, Pearce Melissa B, Davis William G, Zeng Hui, Deyde Varough, Jayashankar Lakshmi, Ranjan Priya, Katz Jacqueline M, Tumpey Terrence M, Fujita Takashi, Sambhara Suryaprakash
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/7/1/102

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http://www.virologyj.com/content/7/1/102

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