Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease

Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease

Decreased expression of brain-derived neurotrophic factor (BDNF) plays an important role in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's disease is neurofibrillary tangles caused by hyperphosphorylation of tau. An in vivo model of Alzheimer'...

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Bibliographic Details
Main Authors: Ai-Hua Xu, Yang Yang, Yong-Xin Sun, Chao-Dong Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; Alzheimer′s disease; exogenous brain-derived neurotrophic factor; Tau protein; okadaic acid; phosphorylation; PP2A-Y307; glycogen synthase kinase-3β; TrkB; cognitive function; brain protection; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2173;epage=2181;aulast=Xu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2173;epage=2181;aulast=Xu

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