Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells

Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells

Abstract Background High levels of the post-translational modification O-GlcNAcylation (O-GlcNAc) are found in multiple cancers, including bladder cancer. Autophagy, which can be induced by stress from post-translational modifications, plays a critical role in maintaining cellular homeostasis and re...

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Bibliographic Details
Main Authors: Lu Jin, Feng Yuan, Guangcheng Dai, Qiu Yao, Han Xiang, Lixia Wang, Boxin Xue, Yuxi Shan, Xiaolong Liu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
O-GlcNAcylation
Autophagy
ULK1
AMPK
Online Access:http://link.springer.com/article/10.1186/s11658-020-00208-x

Internet

http://link.springer.com/article/10.1186/s11658-020-00208-x

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