PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility

PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility

Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway whi...

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Bibliographic Details
Main Authors: Ana E. González Wusener, Ángela González, Fumihiko Nakamura, Carlos O. Arregui
Format: Article
Language:English
Published: The Company of Biologists 2016-01-01
Series:Biology Open
Subjects:
PTP1B
Src
FAK
Integrin
Myosin
Contractility
Online Access:http://bio.biologists.org/content/5/1/32

Internet

http://bio.biologists.org/content/5/1/32

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