Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking

Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking

The strategy of rational approaches to the search for selective COX-2 inhibitors as potential antiinflammatory agents has been proposed and elaborated. It is based on the use of PASS-prediction and molecular docking. The choice of the basic structure of 4-amino-3-thio-1,2,4-triazole as a promising o...

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Bibliographic Details
Main Authors: Natalya Mykolaivna Chalenko, Anna Olegovna Syrovaya, Natalya P Kobzar, Maryna V Rakhimova, Irina A Sych, Igor Vladimirovich Sych
Format: Article
Language:English
Published: Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya 2020-02-01
Series:Borneo Journal of Pharmacy
Subjects:
molecular docking
antiinflammatory activity
1,2,4-triazol-3-thiones
pass
cox-2
Online Access:http://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/1082

Internet

http://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/1082

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