IGFBP3 colocalizes with and regulates hypocretin (orexin).

IGFBP3 colocalizes with and regulates hypocretin (orexin).

The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell loss is still unknown. We performed gene expre...

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Bibliographic Details
Main Authors: Makoto Honda, Krister S Eriksson, Shengwen Zhang, Susumu Tanaka, Ling Lin, Ahmad Salehi, Per Egil Hesla, Jan Maehlen, Stephanie E Gaus, Masashi Yanagisawa, Takeshi Sakurai, Shahrad Taheri, Kuniaki Tsuchiya, Yutaka Honda, Emmanuel Mignot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2617764?pdf=render

Internet

http://europepmc.org/articles/PMC2617764?pdf=render

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