Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner

Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner

Nucleus accumbens-associated protein 1 (NAC1) is a nuclear protein that harbors an amino-terminal BTB domain and a carboxyl-terminal BEN domain. NAC1 appears to play significant and diverse functions in cancer and stem cell biology. Here we demonstrated that the BEN domain of NAC1 is a sequence-spec...

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Bibliographic Details
Main Authors: Naomi Nakayama, Gyosuke Sakashita, Takashi Nagata, Naohiro Kobayashi, Hisashi Yoshida, Sam-Yong Park, Yuko Nariai, Hiroaki Kato, Eiji Obayashi, Kentaro Nakayama, Satoru Kyo, Takeshi Urano
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomedicines
Subjects:
nucleus accumbens-associated protein 1 (NAC1)
BEN (BANP, E5R and NAC1) domain
sequence-specific DNA-binding protein
solution NMR structure
isothermal titration calorimetry (ITC)
Online Access:https://www.mdpi.com/2227-9059/8/12/608

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https://www.mdpi.com/2227-9059/8/12/608

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