Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma

Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma

Abstract Background The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprising the endocannabinoid system (ECS). In this study, we investigated t...

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Bibliographic Details
Main Authors: Mohammed I. Khan, Anna A. Sobocińska, Klaudia K. Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M. Czarnecka, Cezary Szczylik
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
Renal cell carcinoma
Endocannabinoid system (ECS)
CB1 and CB2 receptors
JWH-133
WIN 55,212–2 mesylate
Online Access:http://link.springer.com/article/10.1186/s12885-018-4496-1

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http://link.springer.com/article/10.1186/s12885-018-4496-1

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