IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate

IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate

Vancomycin (VAN)-intermediate-resistant Staphylococcus aureus (VISA) is continually isolated globally, with a systematic review suggesting a prevalence of 2% in all blood culture samples. Most VISA strains exhibit common characteristics, such as a thickened cell wall, reduced autolysis, and attenuat...

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Bibliographic Details
Main Authors: Makoto Kuroda, Tsuyoshi Sekizuka, Hidehito Matsui, Jun Ohsuga, Toshio Ohshima, Hideaki Hanaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
glycopeptide
vancomycin intermediate resistance
genome-wide SNVs
IS256
walKR
lytic enzyme
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01882/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01882/full

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