Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle

Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle

The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase (MLS). Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1−9) isolated from a tropical sponge Cosc...

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Bibliographic Details
Main Authors: So-Hyoung Lee, Tae Hyung Won, Heegyu Kim, Chan-Hong Ahn, Jongheon Shin, Ki-Bong Oh
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Marine Drugs
Subjects:
Candida albicans
isocitrate lyase
Coscinoderma sp.
suvanine sesterterpenes
ICL mutants
Online Access:http://www.mdpi.com/1660-3397/12/10/5148

Internet

http://www.mdpi.com/1660-3397/12/10/5148

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