The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

The ‘ribosomal stress (RS)-p53 pathway’ is triggered by any stressor or genetic alteration that disrupts ribosomal biogenesis, and mediated by several ribosomal proteins (RPs), such as RPL11 and RPL5, which inhibit MDM2 and activate p53. Inosine monophosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate...

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Bibliographic Details
Main Authors: Qi Zhang, Xiang Zhou, RuiZhi Wu, Amber Mosley, Shelya X Zeng, Zhen Xing, Hua Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
Inauhzin
p53
ribosomal stress
IMPDH2
nucleostemin
MDM2
Online Access:https://elifesciences.org/articles/03077

Internet

https://elifesciences.org/articles/03077

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