Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis

<p>Abstract</p> <p>Background</p> <p>Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism <it>Saccharomyces cerevisiae </it>provide only a partial picture of the mechanism of action of a drug.</p> &...

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Bibliographic Details
Main Authors: Giaever Guri, Rebérioux Delphine, Hoon Shawn, McHardy Lianne M, Kemmer Danielle, Nislow Corey, Roskelley Calvin D, Roberge Michel
Format: Article
Language:English
Published: BMC 2009-01-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/9/9