Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult. Via matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to localize renal nucleotides we f...

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Bibliographic Details
Main Authors: Satoshi Miyamoto, Cheng-Chih Hsu, Gregory Hamm, Manjula Darshi, Maggie Diamond-Stanic, Anne-Emilie Declèves, Larkin Slater, Subramaniam Pennathur, Jonathan Stauber, Pieter C. Dorrestein, Kumar Sharma
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:EBioMedicine
Subjects:
Matrix-assisted laser desorption/ionization mass spectrometry imaging
Sphingomyelin
Chronic kidney disease
ATP
AMPK
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301207

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http://www.sciencedirect.com/science/article/pii/S2352396416301207

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