Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

Abstract Background Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified. Results Using whole-body dynamic...

Full description

Bibliographic Details
Main Authors: Xiaobo Li, Hongbao Yang, Shenshen Wu, Qingtao Meng, Hao Sun, Runze Lu, Jian Cui, Yuxin Zheng, Wen Chen, Rong Zhang, Michael Aschner, Rui Chen
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Particle and Fibre Toxicology
Subjects:
Aluminum oxide nanoparticles; PTPN6
Experimental COPD
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12989-017-0234-0

Internet

http://link.springer.com/article/10.1186/s12989-017-0234-0

Similar Items