Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.

Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.

Human pegivirus (HPgV) protects HIV+ people from HIV-associated disease, but the mechanism of this protective effect remains poorly understood. We sequentially infected cynomolgus macaques with simian pegivirus (SPgV) and simian immunodeficiency virus (SIV) to model HIV+HPgV co-infection. SPgV had n...

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Bibliographic Details
Main Authors: Adam L Bailey, Connor R Buechler, Daniel R Matson, Eric J Peterson, Kevin G Brunner, Mariel S Mohns, Meghan Breitbach, Laurel M Stewart, Adam J Ericsen, Christina M Newman, Michelle R Koenig, Emma Mohr, John Tan, Saverio Capuano, Heather A Simmons, David T Yang, David H O'Connor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5675458?pdf=render

Internet

http://europepmc.org/articles/PMC5675458?pdf=render

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