Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.
Human pegivirus (HPgV) protects HIV+ people from HIV-associated disease, but the mechanism of this protective effect remains poorly understood. We sequentially infected cynomolgus macaques with simian pegivirus (SPgV) and simian immunodeficiency virus (SIV) to model HIV+HPgV co-infection. SPgV had n...
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2017-10-01
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Series: | PLoS Pathogens |
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doaj-6ca40416db514a84b26864e30f9bf3cf2020-11-25T00:57:37ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742017-10-011310e100669210.1371/journal.ppat.1006692Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.Adam L BaileyConnor R BuechlerDaniel R MatsonEric J PetersonKevin G BrunnerMariel S MohnsMeghan BreitbachLaurel M StewartAdam J EricsenChristina M NewmanMichelle R KoenigEmma MohrJohn TanSaverio CapuanoHeather A SimmonsDavid T YangDavid H O'ConnorHuman pegivirus (HPgV) protects HIV+ people from HIV-associated disease, but the mechanism of this protective effect remains poorly understood. We sequentially infected cynomolgus macaques with simian pegivirus (SPgV) and simian immunodeficiency virus (SIV) to model HIV+HPgV co-infection. SPgV had no effect on acute-phase SIV pathogenesis-as measured by SIV viral load, CD4+ T cell destruction, immune activation, or adaptive immune responses-suggesting that HPgV's protective effect is exerted primarily during the chronic phase of HIV infection. We also examined the immune response to SPgV in unprecedented detail, and found that this virus elicits virtually no activation of the immune system despite persistently high titers in the blood over long periods of time. Overall, this study expands our understanding of the pegiviruses-an understudied group of viruses with a high prevalence in the global human population-and suggests that the protective effect observed in HIV+HPgV co-infected people occurs primarily during the chronic phase of HIV infection.http://europepmc.org/articles/PMC5675458?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adam L Bailey Connor R Buechler Daniel R Matson Eric J Peterson Kevin G Brunner Mariel S Mohns Meghan Breitbach Laurel M Stewart Adam J Ericsen Christina M Newman Michelle R Koenig Emma Mohr John Tan Saverio Capuano Heather A Simmons David T Yang David H O'Connor |
spellingShingle |
Adam L Bailey Connor R Buechler Daniel R Matson Eric J Peterson Kevin G Brunner Mariel S Mohns Meghan Breitbach Laurel M Stewart Adam J Ericsen Christina M Newman Michelle R Koenig Emma Mohr John Tan Saverio Capuano Heather A Simmons David T Yang David H O'Connor Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. PLoS Pathogens |
author_facet |
Adam L Bailey Connor R Buechler Daniel R Matson Eric J Peterson Kevin G Brunner Mariel S Mohns Meghan Breitbach Laurel M Stewart Adam J Ericsen Christina M Newman Michelle R Koenig Emma Mohr John Tan Saverio Capuano Heather A Simmons David T Yang David H O'Connor |
author_sort |
Adam L Bailey |
title |
Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. |
title_short |
Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. |
title_full |
Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. |
title_fullStr |
Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. |
title_full_unstemmed |
Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. |
title_sort |
pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of hiv infection. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2017-10-01 |
description |
Human pegivirus (HPgV) protects HIV+ people from HIV-associated disease, but the mechanism of this protective effect remains poorly understood. We sequentially infected cynomolgus macaques with simian pegivirus (SPgV) and simian immunodeficiency virus (SIV) to model HIV+HPgV co-infection. SPgV had no effect on acute-phase SIV pathogenesis-as measured by SIV viral load, CD4+ T cell destruction, immune activation, or adaptive immune responses-suggesting that HPgV's protective effect is exerted primarily during the chronic phase of HIV infection. We also examined the immune response to SPgV in unprecedented detail, and found that this virus elicits virtually no activation of the immune system despite persistently high titers in the blood over long periods of time. Overall, this study expands our understanding of the pegiviruses-an understudied group of viruses with a high prevalence in the global human population-and suggests that the protective effect observed in HIV+HPgV co-infected people occurs primarily during the chronic phase of HIV infection. |
url |
http://europepmc.org/articles/PMC5675458?pdf=render |
work_keys_str_mv |
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