Early Weight-Based Aggressive vs. Non-Aggressive Goal-Directed Fluid Resuscitation in the Early Phase of Acute Pancreatitis: An Open-Label Multicenter Randomized Controlled Trial (The WATERFALL Trial), Design, and Rationale

Early Weight-Based Aggressive vs. Non-Aggressive Goal-Directed Fluid Resuscitation in the Early Phase of Acute Pancreatitis: An Open-Label Multicenter Randomized Controlled Trial (The WATERFALL Trial), Design, and Rationale

Treatment options are limited for acute pancreatitis (AP). Early aggressive fluid resuscitation (AFR) has been widely considered beneficial because of theoretical improvement in end-organ perfusion, including the pancreas and gut, with pancreatic necrosis and bacterial translocation as consequences...

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Bibliographic Details
Main Authors: Federico Bolado, James L. Buxbaum, Alicia Vaillo-Rocamora, Karina Cárdenas-Jaén, Patrick Maisonneuve, Enrique de-Madaria
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Medicine
Subjects:
fluid resuscitation
ringer lactate
fluid therapy
acute pancreatitis (AP)
randomized controlled (clinical) trial
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00440/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00440/full

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