A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in C. elegans

A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in C. elegans

Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analysis and Sorter (COPAS) to monitor the fluorescence...

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Bibliographic Details
Main Authors: Mei Han, Wenjuan Zou, Hao Chang, Yong Yu, Haining Zhang, Shitian Li, Hankui Cheng, Guifeng Wei, Yan Chen, Valerie Reinke, Tao Xu, Lijun Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
RNAi screen
synaptic transmission
C. elegans
C2H2 zinc-finger protein
synaptic vesicles
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00141/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00141/full

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