Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach

Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach

Research has shown that FMS-like tyrosine kinase 3 (FLT3) may be a vital drug target for acute myeloid leukemia (AML). However, even though the clinically relevant F691L gatekeeper mutation conferred resistance to current FLT3 drug quizartinib, PLX3397 remained unaffected. In this study, the protein...

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Bibliographic Details
Main Authors: Yunfeng Sun, Zhongni Xia, Qinqin Zhao, Bei Zheng, Meiling Zhang, Yin Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
AML
FLT3
F691L
molecular modeling studies
resistance mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01050/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01050/full

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