G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not

G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not

<p>Abstract</p> <p>Background</p> <p>HIV-2 is endemic in West Africa and has spread throughout Europe. However, the alternatives for HIV-2-infected patients are more limited than for HIV-1. Raltegravir, an integrase inhibitor, is active against wild-type HIV-2, with a s...

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Bibliographic Details
Main Authors: Damond Florence, Collin Gilles, Storto Alexandre, Charpentier Charlotte, Delelis Olivier, Ni Xiao-Ju, Descamps Diane, Mouscadet Jean-François
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Retrovirology
Subjects:
HIV-2
integrase
raltegravir
resistance
mutation
Online Access:http://www.retrovirology.com/content/8/1/68

Internet

http://www.retrovirology.com/content/8/1/68

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