Mitochondrial Deoxyguanosine Kinase Regulates NAD+ Biogenesis Independent of Mitochondria Complex I Activity

Mitochondrial Deoxyguanosine Kinase Regulates NAD+ Biogenesis Independent of Mitochondria Complex I Activity

Overexpression of DGUOK promotes mitochondria oxidative phosphorylation and lung adenocarcinoma progression. However, the role and mechanism of DGUOK in regulation of mitochondria function and lung cancer progression still poorly understood. Here we demonstrated that DGUOK regulated NAD+ biogenesis....

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Bibliographic Details
Main Authors: Lei Sang, Ying-Jie He, Jiaxin Kang, Hongyi Ye, Weiyu Bai, Xiao-Dong Luo, Jianwei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
deoxyguanosine kinase
NAD+
NMNAT2
mitochondria complex I
lung adenocarcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.570656/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.570656/full

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