S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson’s disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslational...

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Bibliographic Details
Main Authors: Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B. McClatchy, Jolene K. Diedrich, John R. Yates, III, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A. Lipton
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
PARK6
PINK1
PARK2
Parkin
Parkinson’s disease
mitophagy
S-nitrosylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315310

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http://www.sciencedirect.com/science/article/pii/S2211124717315310

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