Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model

Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo. To avoid receptor interference and enable dual vector co-infection with MLV-RRV, we have...

Full description

Bibliographic Details
Main Authors: Shih-Han Chen, Jui-Ming Sun, Bing-Mao Chen, Sheng-Che Lin, Hao-Fang Chang, Sara Collins, Deching Chang, Shu-Fen Wu, Yin-Che Lu, Weijun Wang, Thomas C. Chen, Noriyuki Kasahara, Hsin-Ell Wang, Chien-Kuo Tai
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
brain tumor
retroviral replicating vector
prodrug activator
gene therapy
<i>e. coli</i> nitroreductase gene
Online Access:https://www.mdpi.com/1422-0067/21/4/1433

Internet

https://www.mdpi.com/1422-0067/21/4/1433

Similar Items